| Name | CL 316243 |
| Description | CL316243 is a highly potent selective agonist of β3-adrenoceptor, with a EC50 of 3 nM. CL316243 is an effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate. CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence. |
| In vitro | METHODS: We treated rat adipocytes with CL (0.001 - 1 μM) and examined MAPK activation.
RESULTS Treatment of cells with CL for 15 min activated MAPK, but the increase in MAPK activation was not obvious when treated with 1 nM CL, and disappeared when the concentration of CL was increased to 1 μM. [2] |
| In vivo | METHODS: The relaxant effects of different concentrations of CL316243 (0.25-100 g/kg) on the rat lower esophageal sphincter (LES) were recorded before and after continuous infusion of L748337 (0.5 g kg1 min1).
RESULTS CL316243 had a significant, long-term and dose-dependent inhibitory effect on LESP, with little effect on heart rate and mean arterial pressure. [1] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 10 mg/mL (21.47 mM), Sonication is recommended.
H2O : 100 mg/mL (214.69 mM), Sonication is recommended.
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| Keywords | β3-adrenoceptor | Inhibitor | inhibit | CL-316243 | CL316243 | CL 316243 | Beta Receptor | AdrenergicReceptor | Adrenergic Receptor |
| Inhibitors Related | Trifluoperazine dihydrochloride | Mirtazapine | Octopamine hydrochloride | Gemfibrozil | Buflomedil hydrochloride | Dexmedetomidine hydrochloride | Isoprenaline hydrochloride | D-Mannitol | Mianserin hydrochloride | Trazodone hydrochloride | Atenolol | Doxepin hydrochloride |
| Related Compound Libraries | Neuronal Signaling Compound Library | Anti-Obesity Compound Library | Neurotransmitter Receptor Compound Library | Endocrinology-Hormone Compound Library | Adrenergic Receptor-Targeted Compound Library |
United States
