| Name | Cladribine |
| Description | Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases. |
| Cell Research | The non-radioactive cell proliferation kit is used to determine cell viability. In brief, Human MM cell line U266, RPMI8226 and MM1.S are seeded onto 96-well plates with either 0.1 mL complete medium (5% FBS) as control, or 0.1 mL of the same medium containing a series of doses of cladribine, and incubated for 72 hours. After reading all wells at 490 nm with a micro-plate reader, the percentages of surviving cells from each group relative to controls, defined as 100% survival, are determined by reduction of MTS.(Only for Reference) |
| In vitro | In adult zebrafish, intraperitoneal injection of Cladribine (0.7-3.5 mM) was found to inhibit the concentration levels of ATP in RBCs (Red Blood Cells). |
| In vivo | Cladribine inhibits cell growth in primary mast cells (MC) and the MC line HMC-1. It also reduces cell migration ability in CD14+ monocytes as well as CD4+ and CD8+ T lymphocytes. Additionally, Cladribine suppresses cell proliferation in U266, RPMI8226, and MM1.S cells in a dose-dependent manner. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 255 mg/mL (892.58 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (17.5 mM), Sonication is recommended.
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| Keywords | tissue | sclerosis | multiple | mucosa-associated | MCL | mantle | MALT | lymphoma | lymphoid | lymphocytic | leukemia | Inhibitor | inhibit | HCL | hairy | follicular | DLBCL | CLL | Cladribine | chronic | cell | Apoptosis | Adenosinedeaminase | Adenosine deaminase (U266 cells) | Adenosine deaminase (RPMI8226 cells) | Adenosine deaminase (MM1.S cells) | Adenosine Deaminase |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Sildenafil citrate |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
United States
