| Name | Clavulanic Acid |
| Description | Clavulanic Acid(RX-10100), a major beta-lactam antibiotic produced by the organism Streptomyces claveris, is a potent bacterial beta-lactamase inhibitor used in the study of infections caused by bacteria. Clavulanic Acid has a broad spectrum of biological activity and is active against a wide variety of Gram-positive and Gram-negative bacteria. |
| In vitro | Clavulanic acid exhibits synergistic antibacterial activity with ampicillin against microorganisms producing β-lactamase[2].
Clavulanic acid inhibits strains Ab11 and Ab51 with a minimum inhibitory concentration (MIC) ranging from 2 to 8 μg/mL[4]. |
| In vivo | In C57BL/6 mice with Pseudomonas aeruginosa pneumonia, intraperitoneal injection of clavulanic acid (13 mg/kg) reduces bacterial burden in the lungs[4].
In C57BL/6 mice infected with Ab51, intraperitoneal injection of clavulanic acid (13 mg/kg) shows a half-life (t1/2) of 6.69 hours and an area under the curve (AUC) of 4.03 mg·h/L in a lung infection model[4].
In a rat model of carrageenan-induced paw edema, intraperitoneal injection of clavulanic acid (100-300 mg/kg) exhibits anti-inflammatory effects[3]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 10 mg/mL (50.21 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (5.02 mM), Sonication is recommended.
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| Keywords | β-Lactamase | Fungal | Clavulanic Acid |
| Inhibitors Related | Neomycin sulfate | Calcium Propionate | Adipic dihydrazide | Levulinic acid | D(+)-Raffinose pentahydrate | Benzyl propionate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate |
| Related Compound Libraries | Bioactive Compound Library | EMA Approved Drug Library | Anti-Fungal Compound Library | Natural Product Library | Drug Repurposing Compound Library | Inhibitor Library | Microbial Natural Product Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Anti-Infection Compound Library |
United States
