| Name | Clemastine fumarate |
| Description | Clemastine fumarate (Meclastine (fumarate)) is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties. |
| In vitro | In rats, Clemastine Fumarate (5-20 mg/kg) significantly inhibits yeast polysaccharide-induced paw edema and croton oil-induced ear swelling in a dose-dependent manner. |
| In vivo | In HL-60 cells, Clemastine Fumarate (IC50=3 nM) effectively inhibits histamine-induced increases in Ca2+ levels. In the human leukemia cell line K562 and the human B-lymphoblast cell line SB, concentrations of Clemastine Fumarate ≥25 μM significantly suppress both natural killer (NK) cell and antibody-dependent cell-mediated cytotoxicity (ADCC) activities. Additionally, Clemastine Fumarate potently inhibits the HERG K+ channel in HEK 293 cells stably expressing the channel (IC50=12 nM). |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 9 mg/mL (19.57 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.17 mM), Sonication is recommended.
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| Keywords | oral | Meclastine Fumarate | Meclastine | Inhibitor | inhibit | HS-592 | HS592 | HS 592 | HistamineReceptor | Histamine Receptor | H1 receptor | Clemastine Fumarate | Clemastine | Autophagy | anti-inflammatory | antihistamine | allergic reactions |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Tamoxifen | Cysteamine hydrochloride | Guanidine hydrochloride | Hydroxychloroquine | Enzalutamide | Paeonol | Naringin | Alginic acid | Sildenafil citrate |
| Related Compound Libraries | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library |