| Name | CMLD-2 |
| Description | CMLD-2 is an inhibitor of HuR-ARE interaction (Ki: 350 nM) that competitively binds HuR protein and disrupts its interaction with adenine element-rich (ARE) mRNA targets.CMLD-2 induces apoptosis and exhibits antitumor effects through MAD2 downregulation. CMLD-2 (1-75 μM ; 24-72 h) had an inhibitory effect on the viability of thyroid cancer cells.CMLD-2 (20-30 μM ; 24-48 h) activated caspases and induced apoptosis in H1299 and A549 cells.CMLD-2 (30 μM ; 24-48 h) induced G1 cell cycle arrest in H1299 and A549 cells and mitochondrial perturbation. CMLD-2 (30 μM ; 24-48 h) reduced the expression of HuR and HuR-regulated mRNAs and proteins in H1299 cells.CMLD-2 (35 μM ; 72 h) decreased the directional migration ability of SW1736, 8505C, BCPAP and K1 cells.CMLD-2 induced the migration of SW1736, 8505C, BCPAP and K1 cells with a strong decrease in MAD2 mRNA levels. |
| In vitro | CMLD-2 (35 μM ; 72 h) impairs directional migration ability and significantly diminishes MAD2 mRNA levels in SW1736, 8505C, BCPAP, and K1 cells.[2]
CMLD-2 (20-30 μM ; 24-48 h) triggers caspase activation and induces apoptosis in H1299 and A549 cells.[2]
CMLD-2 (30 μM ; 24-48 h) causes G1 cell cycle arrest and disrupts mitochondrial function in H1299 and A549 cells.[2]
CMLD-2 (30 μM ; 24-48 h) decreases the expression of HuR and HuR-regulated mRNAs and proteins in H1299 cells.[2]
CMLD-2 (1-75 μM ; 24-72 h) suppresses thyroid cancer cell viability.[3]
CMLD-2 (0.1-10 μM) reduced the activity of mouse and human sensory neurons.[5] |
| In vivo | CMLD-2 (0.3 μg, 1 μg, 3 μg ; i.pl.) attenuated NGF (left), and IL-6 (right) induced mechanical hypersensitivity during the acute and priming phase in male mice.[5] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 250 mg/mL (486.78 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (3.89 mM), Sonication is recommended.
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| Keywords | CMLD-2 | CMLD2 | CMLD 2 | Apoptosis |
| Inhibitors Related | Stavudine | Aceglutamide | Tamoxifen | Urea | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Dextran sulfate sodium salt (MW 5000) |
| Related Compound Libraries | Apoptosis Compound Library | Bioactive Compound Library | Epigenetics Compound Library | Inhibitor Library | PPI Inhibitor Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
United States
