| Name | Colistin sulfate |
| Description | Colistin sulfate (Colistin sulfate (1066-17-7 free base)) is a cyclic polypeptide antibiotic from Bacillus colistinus, composed of Polymyxins E1 and E2. |
| In vitro | In mice, daily intramuscular injections of Colistin sulfate (15 mg/kg) result in granular degeneration in renal and hepatic epithelial tissues. Similarly, in piglets, daily intramuscular injections of Colistin sulfate (15 mg/kg) lead to significant neurotoxic effects. |
| In vivo | Colistin (2 μg/mL) exhibits broad-spectrum antibacterial activity, effectively inhibiting most strains of Escherichia coli and Pseudomonas aeruginosa, as well as all strains of the genera Enterobacter, Salmonella, Shigella, Pasteurella, Brucella, and Bordetella. Additionally, it is active against strains of the genera Moraxella, Serratia, and Providencia. In 225 strains of P. aeruginosa, the MIC90 and MIC50 of Colistin are 6.3 μg/mL and 1.6 μg/mL, respectively. In Acinetobacter baumannii, Colistin sulfate demonstrates concentration-dependent post-antibiotic effects. |
| Storage | Keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 125.00 mg/mL, Sonication is recommended.
DMSO : Insoluble
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| Keywords | Polymyxin E | Inhibitor | inhibit | Colistin sulfate | Colistin | Cellwall | cell wall | Bacterial | Autophagy | Antibiotic | 1066-17-7 free base | 1066-17-7 |
| Inhibitors Related | Neomycin sulfate | Aceglutamide | Hemin | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Sulfamethoxazole sodium | Terbinafine hydrochloride | Hydroxychloroquine | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate |
| Related Compound Libraries | Target-Focused Phenotypic Screening Library | Cyclic Peptide Library | Antibiotics Library | Natural Product Library | Peptide Compound Library | Microbial Natural Product Library | NO PAINS Compound Library | FDA-Approved Drug Library | Natural Product Library for HTS | Anti-COVID-19 Compound Library | Anti-Infection Compound Library |
United States
