| Name | COR659 |
| Description | COR659 is a 2-acylaminothiophene derivative able to suppress alcohol and chocolate self-administration in rats, likely via positive allosteric modulation of the GABAB receptor and antagonism/inverse agonism at the cannabinoid CB1 receptor. |
| In vitro | COR659 exerts its effects through a composite mechanism, including positive allosteric modulation of the GABAB receptor and action at the cannabinoid CB1 receptor [3]. |
| In vivo | COR659 (0, 2.5, 5, and 10 mg/kg) treatment is completely ineffective on lever-responding (FR10) for regular food pellets in food-deprived Wistar rats[1]. However, COR659 suppresses lever-responding for a sucrose solution in sP rats and a chocolate solution in Wistar rats[2]. Animal Model: Male sP and Wistar rats[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.92 mM), Sonication is recommended. DMSO : 33.33 mg/mL (98.66 mM), Sonication is recommended.
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| Keywords | γ-Aminobutyric acid Receptor | sucrose | Inhibitor | inhibit | Gamma-aminobutyric acid Receptor | GABAReceptor | GABAB | GABA Receptor | COR-659 | COR659 | COR 659 | chocolate | CB1 | CannabinoidReceptor | Cannabinoid Receptor | alcohol |
| Inhibitors Related | β-Caryophyllene | p-Hydroxybenzaldehyde | Urethane | Baicalin | Penicillin G sodium salt | Valproic Acid | Methyl eugenol | 2,3-Butanediol | (-)-α-Pinene | Nipecotic acid | Methionine | Dihydromyricetin |
| Related Compound Libraries | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Neuroprotective Compound Library | Mitochondria-Targeted Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Ion Channel Targeted Library | Anti-Cancer Compound Library |