| Name | CPI-455 |
| Description | CPI-455 is a specific KDM5 inhibitor. |
| Cell Research | All cell lines were treated with DMSO, CPI-4203 or CPI-455 for 5 d with two changes of medium and drug. Thereafter, the cells (PC9, Colo205, Hs888, M14, SKBR3 and EVSA-T) were plated at 2×105 cells in six-well plates in triplicate and treated for an additional 9-15 d, depending on the cell line model. The Incucyte HD imaging system was used to monitor numbers of drug-tolerant cells after cells were stained with Nuclear-ID Red stain. (Only for Reference) |
| In vitro | CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4 trimethylation (H3K4me3) and decreases the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents[1]. CPI-455 has a high measured affinity for the target KDM5 proteins. Within 24 hours, CPI-455 and CPI-766 can dose-dependently increases in H3K4me3, but not H3K4me2. IC50 calculation for KDM5 Inhibitor CPI-455 in 3 luminal breast cancer cell lines MCF-7, T-47 and EFM-19 are 35.4, 26.19 and 16.13 μM, respectively. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 41.67 mg/mL (149.73 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (3.59 mM), Sonication is recommended.
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| Keywords | KDM5A | HistoneDemethylase | Histone Demethylase | CPI-455 | CPI455 | CPI 455 |
| Inhibitors Related | LSD1-IN-24 | Procaine | TFMB-(R)-2-HG | GSK-LSD1 dihydrochloride | GSK-J4 | FY-21 | Phenelzine sulfate | Pulrodemstat HCl | Daminozide | AS8351 | Procaine hydrochloride | Eicosapentaenoic Acid |
| Related Compound Libraries | Highly Selective Inhibitor Library | Methylation Compound Library | Histone Modification Compound Library | Bioactive Compound Library | Inhibitor Library | NO PAINS Compound Library | Stem Cell Differentiation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
United States
