| Name | CPS-11 |
| Description | CPS-11 (N-(Hydroxymethyl)thalidomide) is a Thalidomide analogue with significant antitumor activity, exhibiting a broader and more potent effect on the MM (multiple myeloma) cell line. |
| In vitro | Confirming its ability to target tumor cells in the bone marrow microenvironment, CPS-11 abrogates the ability of bone marrow stromal cells (BMSCs) to induce proliferation of MM cells[1].
Showing virtually no effect on the activation of p38 and only slight, transient activation of ATF2 and HSP27 (0-200 μM, 0 or 4 h), CPS-11 demonstrates its pharmacological behavior[2].
At doses as high as 100 μM, CPS-11 (0-100 μM, 24 or 48 h) exhibits no toxicity to H157 cells, WT MEFs, or the p38α-/- MEFs[2].
Furthermore, CPS-11 (50 μM, 24 or 48 h) does not induce apoptosis in H157 cells[2]. |
| Storage | 02 | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 45 mg/mL (156.11 mM), Sonication is recommended.
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| Keywords | ReactiveOxygenSpecies | Reactive Oxygen Species | Nuclear factor of activated Tcells (NFAT) | NF-κB | NFκB | NF-kB | NFkB | hDHFR(dihydrofolate reductase) | CPS-11 |
| Inhibitors Related | Ethoxyquin | Kaolin | Allopurinol | Cysteamine hydrochloride | Kojic acid | 1,4-Naphthoquinone | Ethyl linoleate | Magnesium acetate tetrahydrate | L-Cystine | N,N-Dimethylacetamide | L-Ascorbic acid sodium salt | Dimethyl phthalate |
| Related Compound Libraries | Anti-Lung Cancer Compound Library | NF-κB Signaling Compound Library | Bioactive Compound Library | HIF-1 Signaling Pathway Compound Library | Anti-Breast Cancer Compound Library | Anti-Obesity Compound Library | Hematonosis Compound Library | Metabolism Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |
United States
