| Name | CSF1R-IN-2 |
| Description | CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively). |
| In vitro | The suppression of MET autophosphorylation as well as the downstream STAT3 caused by CSF1R-IN-2, ERK and AKT phosphorylation at IC50 values of around 1-3 nM in SNU-5 and MKN-45 cell lines. |
| In vivo | In mice, CSF1R-IN-2 (p.o., BID, 13 days) treatment results in an 85% tumor regression, and no bodyweight loss is observed after 21 days of treatment. In SCID/Beige mice. CSF1R-IN-2 (p.o., BID, 10 days) demonstrates the ability to inhibit tumor growth at 44% and 67% at the dose of 5 mg/kg, BID, and 15 mg/kg, BID, respectively. In mice, CSF1R-IN-2 inhibits MET activity in MKN-45 tumors following oral administration. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 25 mg/mL (61.06 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween-80+45% Saline : 2 mg/mL (4.88 mM), Sonication is recommended.
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| Keywords | SRC | MET | Inhibitor | inhibit | HGFR | CSF1R-IN-2 | CSF-1R-IN-2 | CSF1RIN2 | CSF1R IN 2 | CSF-1R | CSF1R | CSF-1 receptor | colony stimulating factor 1 receptor | c-Met/HGFR | cMet/HGFR | c-Met | cMet | c-FMS | cFms |
| Inhibitors Related | (S)-Afatinib | Vemurafenib | PLX5622 | Decanoic Acid | Afatinib Dimaleate | Dasatinib | Ibrutinib | Pexidartinib | Crizotinib | iHCK-37 | Afatinib | Bacitracin Zinc |
| Related Compound Libraries | Anti-Lung Cancer Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Anti-Cancer Metabolism Compound Library | Angiogenesis related Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Anti-Cancer Compound Library |
United States
