| Name | CTPI-2 |
| Description | CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with(KD : 3.5 μM). CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 exhibits anti-tumor activity.CTPI-2 halts salient alterations of NASH reverting steatosis, preventing the evolution to steatohepatitis, reducing inflammatory macrophage infiltration in the liver and adipose tissue, and starkly mitigating obesity induced by a high-fat diet. |
| In vivo | CTPI-2, halts salient alterations of NASH reverting steatosis, preventing the evolution to steatohepatitis, reducing inflammatory macrophage infiltration in the liver and adipose tissue, while starkly mitigating obesity induced by a high-fat diet.?These effects are differentially recapitulated by a global ablation of one copy of the Slc25a1 gene or by a liver-targeted Slc25a1 knockout, which unravel dose-dependent and tissue-specific functions of this protein.?Mechanistically, through citrate-dependent activities, Slc25a1 inhibition rewires the lipogenic program, blunts signaling from peroxisome proliferator-activated receptor gamma, a key regulator of glucose and lipid metabolism, and inhibits the expression of gluconeogenic genes.?The combination of these activities leads not only to inhibition of lipid anabolic processes, but also to a normalization of hyperglycemia and glucose intolerance as well[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.61 mM), Sonication is recommended.
DMSO : 250 mg/mL (700.79 mM), Sonication is recommended.
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| Keywords | transporter | steatosis | steatohepatitis | SLC25A1 | NSCLC | MitochondrialMetabolism | Mitochondrial Metabolism | mitochondrial | macrophage | Inhibitor | inhibit | inflammatory | glucose | CTPI-2 | CTPI2 | CTPI 2 | citrate | carrier |
| Inhibitors Related | Ciprofloxacin hydrochloride monohydrate | 1-Hexanol | Imeglimin hydrochloride | Rotenone | Glibenclamide | Permethrin | Ciprofloxacin monohydrochloride | (-)-Epigallocatechin Gallate | Phosphocreatine disodium | Sodium Molybdate | 4-Pentenoic acid | L-Histidine |
| Related Compound Libraries | Reprogramming Compound Library | Glycometabolism Compound Library | Bioactive Compound Library | Anti-Obesity Compound Library | Inhibitor Library | NO PAINS Compound Library | Metabolism Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
United States
