| Name | Cucurbitacin E |
| Description | Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1/CDC2 complex.Cucurbitacin E has prevention of neurodegeneration, it has potent anti-proliferative, antineoplastic, anti-inflammatory and analgesic actions. |
| In vitro | the anti-proliferation and cell cycle G2/M arrest induced by Cucurbitacin E (CuE)?in CRC cells.?MPM-2 flow cytometry tests show that CuE-treated cells accumulated in metaphase (CuE 2.5-7.5 μM).?CuE produced G2/M arrest as well as the downregulation of CDC2 and cyclin B1 expression and dissociation.?Both effects increased proportionally with the dose of CuE;?however, the inhibition of proliferation, arrest of mitosis, production of reactive oxygen species (ROS), and loss of mitochondrial membrane potential (ΔΨm) were found to be dependent on the quantity of CuE used to treat the cancer cells.?In addition, cell cycle arrest in treated cells coincided with the activation of the gene GADD45(α, β, γ).?Incubation with CuE resulted in the binding of GADD45γ to CDC2, which suggests that the delay in CuE-induced mitosis is regulated by the overexpression of GADD45γ.?CuE may have antitumor activities in established CRC[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Corn Oil : 2.5 mg/mL (4.49 mM), Sonication is recommended.
DMSO : 150 mg/mL (269.45 mM), Sonication is recommended.
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| Keywords | α-Elaterine | α-Elaterin | VEGFR | TNF-α | STAT | ROS | p65 | p38 MAPK | p21 | NF-κB | JAK | Inhibitor | inhibit | IL Receptor | ERK | Cyclin dependent kinase | Cucurbitacin E | CDK1/cyclinB1 | CDK | Caspase | Autophagy |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Tamoxifen | Cysteamine hydrochloride | 2-Chloropyrazine | Guanidine hydrochloride | Hydroxychloroquine | Enzalutamide | Paeonol | Naringin | Alginic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Terpene Natural Product Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Kinase Inhibitor Library | Natural Product Library | Tobacco Monomer Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Anti-Cancer Active Compound Library |
United States
