| Name | Cycloleucine |
| Description | Cycloleucine is an antagonist of NMDA receptor associated glycine receptor with a Ki of 600 μM. Cycloleucine is also a competitive inhibitor of S-adenosyl-methionine mediated methylation with anxiolytic and cytostatic effects. |
| In vitro | Cytostatic (10 µg/mL) inhibits the viability of human KB and mouse L1210s leukemia cell lines. Cycloleucine (4-40 mM; 3 h) blocks internal methylation of viral RNA in B77 transformed chick embryo fibroblasts. Cycloleucine (40 mM; 24 h) blocks the formation of both m6A and the penultimate Gm in B77 38S RNA subunits by greater than 90%[2]. |
| In vivo | Cycloleucine (0.5, 1.0, 2.0, 4 µg/µL; intracerebroventrically) increases time spent in open arms, open arm entries, and extreme arrivals in rats[3]. In Semliki Forest virus strain A7(74) infected and control mice, Cycloleucine reduces thymus and spleen weights[4]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 51.5 mg/mL (398.73 mM), Sonication is recommended.
DMSO : < 1 mg/mL (insoluble or slightly soluble), Sonication is recommended.
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| Keywords | transferase | nucleic | NMDA receptor | NMDA | methylations | Ionotropic glutamate receptors | Inhibitor | inhibit | iGluR | glycine | cytostatic | Cycloleucine | ATP | anxiolytic |
| Inhibitors Related | Urethane | Decanoic Acid | N-Methylsarcosine | L-Glutamic acid | N,N-Dimethylglycine hydrochloride | L-Phenylalanine | glycine | Halothane | Indole-2-carboxylic acid | L-Glutamic acid monosodium salt | Memantine | Memantine hydrochloride |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Antidepressant Compound Library | Neuronal Signaling Compound Library | Neurotransmitter Receptor Compound Library | CNS-Penetrant Compound Library | Inhibitor Library | Neuroprotective Compound Library | Bioactive Compounds Library Max | Human Metabolite Library |
United States
