| Name | Cyproheptadine |
| Description | Cyproheptadine is an orally active serotonin 5-HT2A receptor antagonist with multiple pharmacological properties including antidepressant, anti-serotonin, antiplatelet, and antithrombotic effects. Cyproheptadine is used as a research compound for investigating thromboembolic diseases, serotonergic signaling, and potential links between serotonin modulation and metabolic disorders such as diabetes. |
| In vitro | In in vitro experiments, Cyproheptadine (0.01–100 nM, 1 minute) dose-dependently inhibited serotonin-enhanced ADP-induced mouse platelet aggregation [2]; at a concentration of 10 nM, Cyproheptadine suppressed 15 μM serotonin-potentiated 1 μM ADP-induced platelet tyrosine phosphorylation [2]; Cyproheptadine also inhibited activation markers of homo sapiens platelets, including phosphatidylserine (PS) exposure (detected by annexin V), P-selectin (CD62P), and the GPIIb-IIIa complex (assessed via PAC-1 binding) [2]. |
| In vivo | Cyproheptadine (1 mg/kg, intraperitoneal injection, once daily for 5 consecutive days) significantly prolonged the arterial occlusion time and tail bleeding time in C57BL/6 mice [2]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 2 mg/mL (6.96 mM), when pH is adjusted to 3 with HCl. Sonication is recommended.
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| Inhibitors Related | Alverine citrate | Sevoflurane | Dapoxetine hydrochloride | Cefaclor monohydrate | Clozapine N-Oxide | 1,8-Cineole | Dopamine hydrochloride | Cloperastine hydrochloride | Mianserin hydrochloride | Trazodone hydrochloride | Cinchonidine | Doxepin hydrochloride |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Approved Drug Library | Neuronal Signaling Compound Library | ReFRAME Related Library | Drug Repurposing Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Serotonin Receptor-Targeted Compound Library | Human Metabolite Library |
United States
