| Name | D-64131 |
| Description | D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM. |
| In vitro | D-64131 dose-dependently inhibited the polymerization of bovine brain microtubulin and the binding of [3H]colchicine to biotinylated αβ-microtubulin. After treatment with D-64131, many Y cells displayed abnormal microtubule structures, such as divided mitotic spindles or multiple spindle poles. Nuclear vesicles and abnormal nuclear structures typical of apoptotic cells were detected in many cells treated with D-64131. |
| In vivo | D-64131 dose-dependently inhibited the polymerization of bovine brain microtubulin and the binding of [3H]colchicine to biotinylated αβ-microtubulin. After treatment with D-64131, many Y cells displayed abnormal microtubule structures, such as divided mitotic spindles or multiple spindle poles. Nuclear vesicles and abnormal nuclear structures typical of apoptotic cells were detected in many cells treated with D-64131. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 25.1 mg/mL (99.89 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (7.96 mM), Sonication is recommended.
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| Keywords | tubulin-inhibitory | Tubulin polymerization | phase | MicrotubuleAssociated | Microtubule/Tubulin | Microtubule Associated | Inhibitor | inhibit | G2/M | D-64131 | D64131 | D 64131 | cytotoxicity | carcinoma | astrocytoma | antiproliferative | antimitotic | activity |
| Inhibitors Related | Flubendazole | N-Phenylbenzylamine | Mebendazole | 4-Isopropoxybenzoic acid | Pregnenolone acetate | Oxfendazole | α-Cyclodextrin | Methylene Blue trihydrate | Paclitaxel | 4'-Demethylepipodophyllotoxin | Albendazole | Colchicine |
| Related Compound Libraries | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | ReFRAME Related Library | Microtubule-Targeted Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library | High-Efficiency Gene Editing Small Molecule Library |
United States
