| Name | D-Galactose |
| Description | D-Galactose is a naturally occurring hexose and a C-4 epimer of glucose. It can combine with glucose to form lactose and is commonly used to establish animal models of aging. |
| In vitro | Galactose is important for the survival and virulence of bacteria. Galactose is utilized by the Leloir pathway in Escherichia coli. Two anomers of d-galactose are used for different purposes, α-d-galactose as a carbon source and β-d-galactose for induction of UDP-galactose synthesis for biosynthetic glycosylation[1]. |
| In vivo | Chronic D-galactose exposure induces neurodegeneration by enhancing caspase-mediated apoptosis and inhibiting neurogenesis and neuron migration in mice, as well as increasing oxidative damage. Moreover, D-galactose-induced toxicity in mice is a useful model for studying the mechanisms of neurodegeneration and neuroprotective drugs and agents[2]. D-galactose given by oral route leads to cognitive impairments in rats which are accompanied by oxidative damage. Cognitive impairments is observed in the open-field test in the 4th and 6th weeks after d-gal administration, as well as an impairment in spatial memory in the radial maze test after the 6th week of d-gal administration[3]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 66 mg/mL (366.34 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (18.32 mM), Sonication is recommended.
DMSO : 86.6 mg/mL (480.68 mM), Sonication is recommended.
|
| Keywords | α-D-galactose | EndogenousMetabolite | Endogenous Metabolite | D-Galactose | DGalactose | D Galactose | a-D-galactose |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Formamide | Glycerol | Thymidine | Corn starch | Hyaluronic acid sodium (MW 20 kDa) | Gluconate Calcium |
| Related Compound Libraries | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Drug Repurposing Compound Library | Saccharide and Glycoside Natural Product Library | Miao medicine Compound Library | Natural Product Library | Tobacco Monomer Library | Natural Product Library for HTS | Cosmetic Ingredient Compound Library | Bioactive Compounds Library Max | Gut Microbial Metabolite Library | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library |
United States
