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ChemicalBook Product Catalog Biochemical Engineering Biochemical Reagents Agonist Inhibitors DAMGO

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DAMGO NEW

$43.00 1mg

$55.00 2mg

$79.00 5mg

Min. Order
Purity99.94%
Cas No78123-71-4
Supply Ability10g
Update time2026-04-10

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP6Y

United States

United States

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Chemical Properties

Product Name	DAMGO
CAS No	78123-71-4
EC-No
Min. Order
Purity	99.94%
Supply Ability	10g
Release date	2026/04/10

Product Introduction

Bioactivity

Name	DAMGO
Description	DAMGO (DAGO) is an opioid receptor agonist with the ability to affect the locomotive activity in rodents. Possible analgesic agent due to μ-opiod receptor interaction.
In vivo	(1) DAMGO inhibits GABAergic inputs in VTA-DA neurons at presynaptic sites; (2) effect of DAMGO on GABAergic inputs in VTA-DA neurons is inhibited by potassium channel blocker 4-aminopyridine (4-AP) and Gi protein inhibitor N-ethyl maleimide (NEM); (3) phospholipase A2 (PLA2) does not mediate the effect of DAMGO on GABAergic inputs in VTA-DA neurons, but mediates it in the periaqueductal gray (PAG); (4) multiple downstream signaling molecules of l receptors do not mediate the effect of DAMGO on GABAergic inputs in VTA-DA neurons. These results suggest that DAMGO depresses inhibitory synaptic transmission via l receptor-Gi protein-Kv channel pathway in VTA-DA neurons, but via l receptor-PLA2 pathway in PAG
Storage	Store at low temperature,Keep away from moisture \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (3.89 mM), Sonication is recommended. DMSO : 145 mg/mL (282.33 mM), Sonication is recommended.
Keywords	μ-OPR \| μ-opioid receptor \| RX783006 \| RX 783006 \| OpioidReceptor \| Opioid Receptor \| DAMGO \| analgesic effect
Inhibitors Related	Docusate sodium \| Bevenopran \| Mirtazapine \| (-)-Menthol \| Cuminaldehyde \| Progesterone \| Naltrexone hydrochloride \| Cebranopadol \| BTRX-335140 \| Bisacodyl \| Loperamide hydrochloride \| Mianserin hydrochloride
Related Compound Libraries	Bioactive Compound Library \| Anti-Neurodegenerative Disease Compound Library \| Pain-Related Compound Library \| Neuronal Signaling Compound Library \| Membrane Protein-targeted Compound Library \| Anti-Parkinson's Disease Compound Library \| Neurotransmitter Receptor Compound Library \| Peptide Compound Library \| NO PAINS Compound Library \| Bioactive Compounds Library Max \| GPCR Compound Library \| Anti-Cancer Compound Library

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