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ChemicalBook Product Catalog Chemical Reagents Organic reagents Aromatic acids Dapagliflozin Intermediate/ Empagliflozin Intermediate/ 5-Bromo-2-Chlorobenzoic Acid

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Dapagliflozin Intermediate/ Empagliflozin Intermediate/ 5-Bromo-2-Chlorobenzoic Acid

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Min. Order2Kg/Bag
Purity99% up, High Density
Cas No21739-92-4
Supply Ability20 tons
Update time2026-04-14

Sinoway Industrial co., ltd.

VIP5Y

China

Since:1996-07-16

Address:16F,HUICHENG COMM,839 XIAHE ROAD,XIAMEN CHINA

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Chemical Properties

Product Name	Dapagliflozin Intermediate/ Empagliflozin Intermediate/ 5-Bromo-2-Chlorobenzoic Acid
CAS No	21739-92-4
EC-No
Min. Order	2Kg/Bag
Purity	99% up, High Density
Supply Ability	20 tons
Release date	2026/04/14

Product Information

Product name	5-Bromo-2-chlorobenzoic acid
Synonyms	5-bromo-2-chloro-benzoate;5-bromo-2-chloro-benzoic acid;2-Chloro-5-bromobenzoic acid;5-Bromo-2-Chloro Benzoic Acid;2-Chloro-5-Bromo Benzoic Acid;
CAS No.	21739-92-4
Molecular Formula	C7H4BrClO2
Molecular Weight	235.465
Molecular Structure
Quality Standard	99% up by HPLC
Appearance	White to off-white powder

Usage

The characteristics of 5-Bromo-2-chlorobenzoic acid can be summarized as:

(1)ACD/LogP: 2.79;

(2)# of Rule of 5 Violations: 0;

(3)ACD/LogD (pH 5.5): 0.02;

(4)ACD/LogD (pH 7.4): -0.35;

(5)ACD/BCF (pH 5.5): 1;

(6)ACD/BCF (pH 7.4): 1;

(7)ACD/KOC (pH 5.5): 1.32;

(8)ACD/KOC (pH 7.4): 1;

(9)#H bond acceptors: 2;

(10)#H bond donors: 1;

(11)#Freely Rotating Bonds: 1;

(12)Index of Refraction: 1.621;

(13)Molar Refractivity: 45.76 cm3;

(14)Molar Volume: 130 cm3;

(15)Polarizability: 18.14×10-24 cm3;

(16)Surface Tension: 55.9 dyne/cm;

(17)Enthalpy of Vaporization: 59.81 kJ/mol;

(18)Vapour Pressure: 0.0001 mmHg at 25°C;

(19)Rotatable Bond Count: 1;

(20)Exact Mass: 233.90832;

(21)MonoIsotopic Mass: 233.90832;

(22)Topological Polar Surface Area: 37.3;

(23)Heavy Atom Count: 11;

(24)Complexity: 163.

Preparation of 5-Bromo-2-chlorobenzoic acid: It can be obtained by 1-bromo-4-chloro-benzene and carbon dioxide. This reaction needs reagent 2,2,6,6-tetramethylpiperidine, butyllithium and solvent tetrahydrofuran and hexane at temperature of -75 °C. The reaction time is 2 hours. The yield is 52%.

Uses of 5-Bromo-2-chlorobenzoic acid: It can be used to produce 2-chloro-5-deuteriobenzoic acid. This reaction needs reagent sodium carbonate, Raney Cu-Al alloy and solvent D2O at temperature of 65 °C. The reaction time is 8 hours. The yield is 88%.

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Company Profile Introduction

Sinoway Industrial co., ltd. was established in 1987 in Xiamen, China, and now has been a leading group specialized in research, development, custom manufacturing and trading of pharmaceutical intermediates, APIs, health and food supplements, cosmetic raw materials, herbal extracts, polypeptides and prostaglandin derivatives, etc.. We have passed ISO9001:2015. With qualified products, competitive price and excellent service, we have received great reputation of our customers from all over the world, including Southeast Asia, Europe, North America, South America, Middle East and other countries. We have over 20 years good partners in Japan、Korea and Switzerland. Sinoway has a professional R&D team. We have built close cooperative relationships with many research institutes and universities in China. Moreover, Sinoway combines market analysis with technology, providing new business trends to our clients. In addition, we have very close cooperation relationships with many Chinese pharmaceutical factories. These pharmaceutical manufacturers have GMP regulated workshops, advanced production and testing equipments, first-class QC labs and a production team with rich experience. We can supply various Active Pharmaceutical Ingredients and finished products which meet EP/USP/BP standards. Chinese GMP, EU-GMP, COS/CEP certificates with DMF documents are available, and many products have been approved by FDA. We believe that quality and innovation are vital for an enterprise. Adhering to the business philosophy of integrity and win-win cooperation, Sinoway is looking forward to have a bright future with you together.