| Name | Daporinad hydrochloride |
| Description | Daporinad hydrochloride (FK 866 hydrochloride) is a potent nicotinamide-phosphate ribosyltransferase (NAMPT) inhibitor with potential anti-tumor and anti-angiogenic activity that induces apoptosis in tumor cells.Daporinad hydrochloride can be used in the study of inflammation and cancer. |
| In vitro | METHODS: RPMI8226/S, U266 and MM1S cells were treated with FK866 (10nM, 24-48 hours) to study the effect of Nampt inhibitor on MAPK signaling pathway in MM cells.
RESULTS: FK866 significantly reduced the gene and protein levels of pERK1/2, pp38MAPK and pSAPK/JNK, indicating that the drug has an effective inhibitory effect on MEK/ERK signaling. [1] |
| In vivo | METHODS: CB17-SCID mice injected with MM1S cells were treated with FK866 (30 mg/kg, intraperitoneal injection, twice a day, for 4 days) once a week for 3 weeks. Caliper measurements of the longest perpendicular tumor diameter were taken twice a week, and excised tumors were collected from mice for Western blot analysis to assess ERK and LC3B phosphorylation.
RESULTS: A significant reduction in tumor burden was observed on day 7 of FK866 treatment, the treatment was well tolerated, without significant weight loss or neurological changes, and resulted in a significant prolongation of overall survival; tumor tissues from FK866-treated mice showed a significant reduction in ERK phosphorylation and LC3 proteolytic cleavage. [1] |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 10 mg/mL (23.37 mM), Sonication is recommended.
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| Keywords | NAMPT | FK-866 Hydrochloride | FK866 Hydrochloride | FK 866 hydrochloride (658084641 free base) | FK 866 hydrochloride (658084 64 1 free base) | Apoptosis | 658084-64-1 free base | 658084-64-1 |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Sildenafil citrate |
United States
