| Name | Darglitazone |
| Description | Darglitazone (CP-86325) is a potent, selective agonist of PPAR-γ with antidiabetic actions. Darglitazone is effective in controlling blood glucose and lipid metabolism. |
| In vitro | Darglitazone (30 μM) stimulated UCP2 gene expression, likely through PPAR-γ, and increased UCP2 mRNA levels in cell lines representing white (3T3-L1 and 3T3-F442A), brown (HIB-1B) adipose tissues, and skeletal muscle (L6) [1]. |
| In vivo | In male diabetic ob/ob mice, Darglitazone dramatically reduces the infarct size in the ob/ob mice at 24?h of recovery. Normalized blood glucose and reduced circulating triglycerides (TG) and very-low-density lipoproteins (VLDL) in diabetic ob/ob mice without having any effect in the nondiabetic mice. Darglitazone treatment restores acute cerebral inflammatory responses that were absent in the diabetic mice and profoundly improved their recovery from hypoxic-ischemic (H/I) insult[2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 55 mg/mL (130.8 mM), Sonication is recommended. Ethanol : ≤ 5 mg/mL, Sonication is recommended. 10% DMSO+90% Corn Oil : 2.5 mg/mL (5.95 mM), Sonication is recommended.
|
| Keywords | UCP2 | thiazolidinedione | PPAR-γ | PPARγ | PPAR | Peroxisome proliferator-activated receptors | oral | Inhibitor | inhibit | Diabetes | Darglitazone | CP86325 | CP 86325 | corticosterone |
| Inhibitors Related | PHYTOL | Rosiglitazone | Retinoic acid | Daidzein | Fenofibrate | Magnesium acetate tetrahydrate | Maltitol | Naringenin | 2,3-Butanediol | NPC 15199 | Icariin | Cloxiquine |
| Related Compound Libraries | Ferroptosis Compound Library | DNA Damage & Repair Compound Library | Bioactive Compound Library | Anti-Alzheimer's Disease Compound Library | ReFRAME Related Library | Anti-Diabetic Compound Library | Anti-Breast Cancer Compound Library | Orally Active Compound Library | Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Human Metabolite Library |