| Name | DC-05 |
| Description | DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively). |
| In vitro | DC-05 is a non-nucleoside DNMT1 inhibitor with low micromolar IC50 values and significant selectivity toward other AdoMet-dependent protein methyltransferases.?DC-05 (1.25, 2.5, 5, and 10 μM) effectively inhibits the proliferation of HCT116 (human colon cancer) and Capan-1 (human pancreatic adenocarcinoma cells) after treatment for 24, 48, and 72 h. DC-05 displays poor potent activities against DNMT3A, DNMT3B, G9a, SUV39H1, MLL1, SET7/9, and PRMT1 (IC50: >200, >200, >150, >150, >150, >150, 37.1 μM) [1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 250 mg/mL (651.91 mM), Sonication is recommended. 10% DMSO+90% Corn Oil : 3.3 mg/mL (8.61 mM), Sonication is recommended.
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| Keywords | PRMT1 | Inhibitor | inhibit | HistoneMethyltransferase | Histone Methyltransferase | DNMTs | DNMT1 | DNAMethyltransferase | DNA MTases | DNA methyltransferase (DNMT) | DNA Methyltransferase | DC-05 | DC05 | DC 05 |
| Inhibitors Related | MAK-683 hydrochloride | SNDX-5613 | Levetiracetam | Tazemetostat | Piribedil | XY1 | EPZ015666 | iso-Azalansta | CBHcy | γ-Oryzanol | MRTX-1719 | Hinokitiol |
| Related Compound Libraries | Methylation Compound Library | Histone Modification Compound Library | Reprogramming Compound Library | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Epigenetics Compound Library | Hematonosis Compound Library | Inhibitor Library | Stem Cell Differentiation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library |