| Name | Dehydroevodiamine hydrochloride |
| Description | Dehydroevodiamine (DHE), a natural compound isolated from Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production. |
| Animal Research | The effects of dehydroevodiamine·HCl (DHED) on cognitive improvement and the related mechanism in memory-impaired rat models, namely, a scopolamine-induced amnesia model and a Aβ1-42-infused model. The cognitive effects of DHED were measured using a water maze test and a passive avoidance test in the memory-impaired rat models. The results demonstrate that DHED (10 mg/kg, p.o.) and Donepezil (1 mg/kg, p.o.) ameliorated the spatial memory impairment in the scopolamine-induced amnestic rats. |
| In vivo | Dehydroevodiaminehydrochloride has strong protective effects against cognitive impairments through its antioxidant activity and inhibition of neurotoxicity and intracellular calcium. Thus, DHED may be an important therapeutic agent for memory-impaired symptoms. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.96 mM), Sonication is recommended.
DMSO : 37 mg/mL (109.53 mM), Sonication is recommended.
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| Keywords | Inhibitor | inhibit | Dehydroevodiamine Hydrochloride | Dehydroevodiamine | AChE |
| Inhibitors Related | Sodium propionate | Kojic acid | Acetaminophen | Fumaric acid | 1,4-Naphthoquinone | Ethyl linoleate | N,N-Dimethylacetamide | Methylene Blue trihydrate | Trometamol | Gluconate Calcium | Dimethyl sulfoxide | Coumaran |
| Related Compound Libraries | NF-κB Signaling Compound Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Neuronal Signaling Compound Library | Alkaloid Natural Product Library | Membrane Protein-targeted Compound Library | Neuroprotective Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Transcription Factor-Targeted Compound Library |
United States
