| Name | Demethylisoencecalin |
| Description | Demethylisoencecalin (6-Acetyl-5-hydroxy-2,2-dimethyl-2H-1-benzopyran) has anti-hyperglycemic activity. |
| In vitro | Demethylisoencecalin (1) and caleins A (4) and C (5) (3.16–31.6 mg/kg, p.o.), the major components from an infusion of Calea ternifolia controlled postprandial glucose levels during an oral sucrose tolerance test (OSTT, 3 g/kg) in normal and nicotinamide/streptozotocin (NA/STZ, 40/100 mg/kg) hyperglicemic mice. The effects were comparable to those of acarbose (5 mg/kg). During the isolation of 1, 4, and 5, four additional metabolites not previously reported for the plant, were obtained, namely 6-acetyl-5-hydroxy-2-methyl-2-hydroxymethyl-2H-chromene (3), herniarin (6), scoparone (7), and 4′,7-dimethylapigenin (8). In addition, the structure of calein C (5) was confirmed by X-ray analysis. Pharmacological evaluation of the essential oil of the species (31.6–316.2 mg/kg, p.o.) provoked also an important decrement of blood glucose levels during an OSTT[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 60 mg/mL (274.91 mM), Sonication is recommended.
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| Keywords | Demethylisoencecalin |
| Inhibitors Related | Cedryl acetate | X-GAL | Hexylresorcinol | Conduritol B epoxide | Gcase activator 2 | Fucoidan | Miglitol | D-(-)-Quinic acid | (E)-3-(4-Methoxyphenyl)acrylic acid | Naringinase | Acarbose | 3-Butylidenephthalide |
| Related Compound Libraries | Bioactive Compound Library | Rare Natural Product Library | Selected Plant-Sourced Compound Library | Natural Product Library | Natural Product Library for HTS | Metabolism Compound Library | RO5 Drug-like Natural Product Library | Bioactive Compounds Library Max |
United States
