| Name | Dersimelagon |
| Description | Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist with EC50 values of 8.16, 3.91, 1.14, and 0.251 nM for human (h), cynomolgus monkey (cm), mouse (m), and rat (r) MC1R, respectively. Dersimelagon exhibits good affinity for hMC1R and hMC4R, with Ki values of 2.26 and 32.9 nM, respectively. Dersimelagon can be used in the study of skin pigmentation[1]. |
| In vitro | METHODS: B16F1 cells were treated with Dersimelagon (MT-7117) (0, 0.03, 0.1, 0.3, 1, 3, 10, 30, 100, 300 pM; 3 days) to evaluate the ability of Dersimelagon (MT-7117) to induce eumelanin production.
RESULTS Dersimelagon (MT-7117) increased eumelanin production in a concentration-dependent manner with an EC50 of 13 pM in B16F1 cells. [1] |
| In vivo | METHODS: Dersimelagon (MT-7117) (0.003, 0.03, 0.3, 3 mg/kg; oral administration for 6 days) was used to observe the effect of Dersimelagon (MT-7117) on the hair of Ay/a mice.
RESULTS MT-7117 induced the synthesis of eumelanin, but not pheomelanin, in the hair roots of Ay/a mice. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 6.76 mg/mL (10 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (1.48 mM), Sonication is recommended.
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| Keywords | MT7117 | MT 7117 | MelanocortinReceptor | melanocortin-1 receptor | Melanocortin Receptor | Dersimelagon |
| Inhibitors Related | (±)-Eriodictyol | α-MSH | 4-Methyl-6-Methoxycoumarin | Fenoprofen Calcium | α-MSH acetate | BMS-470539 dihydrochloride | Bremelanotide | ACTH (1-17) acetate | Tetracosactide acetate | 2-MNG | Undecylenoyl phenylalanine | Bremelanotide Acetate |
| Related Compound Libraries | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Drug Repurposing Compound Library | Orally Active Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | GPCR Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library |
United States
