| Name | Desmethylglycitein |
| Description | Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer activities. |
| In vitro | Molecular studies showed that Desmethylglycitein significantly inhibited acetylcholinesterase and thiobarbituric acid reactive substance (TBARS) activities in the hippocampus of scopolamine-induced mice.In addition, immunohistochemistry and Western blot results revealed that Desmethylglycitein significantly increased brain-derived neurotrophic factor (BDNF) and phosphor cAMP response element binding (CREB) in the hippocampus of mice. |
| In vivo | A single administration of Desmethylglycitein significantly improved scopolamine-induced cognitive dysfunction in these in vivo tests.Moreover, treatment with Desmethylglycitein alone enhanced learning and memory performance in the same behavioral tests. Desmethylglycitein improves cognitive dysfunction induced by scopolamine and enhances learning and memory by activation of the cholinergic system and the p-CREB/BDNF signaling pathway in mice |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 247.5 mg/mL (915.85 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (14.8 mM), Sonication is recommended.
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| Keywords | Protein kinase C | PKCα | PKC | PI3K | Phosphoinositide 3-kinase | Inhibitor | inhibit | Desmethylglycitein | Cyclin dependent kinase | CDK2 | CDK1 | CDK | 4',6,7-Trihydroxyisoflavone |
| Inhibitors Related | Ribociclib | Musk ketone | 2-Chloropyrazine | Kojic acid | Myricetin | Creatine monohydrate | Hyaluronic acid | α-Vitamin E | Abemaciclib | Isoprenaline hydrochloride | Methyl eugenol | Quercetin |
| Related Compound Libraries | Polyphenolic Natural Product Library | Flavonoid Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Kinase Inhibitor Library | Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | TGF-beta/Smad Compound Library |
United States
