| Name | Dexpramipexole dihydrochloride |
| Description | Dexpramipexole dihydrochloride (KNS-760704 dihydrochloride) ((R)-Pramipexole dihydrochloride) is a neuroprotective agent and is a weak non-ergoline dopamine agonist. |
| In vitro | Dextromethorphan has been found to have neuroprotective effects and is being studied for the treatment of amyotrophic lateral sclerosis (ALS). Dexpramipexole reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptosis pathways, and improves cell survival in response to various neurotoxins and β-amyloid neurotoxicity. Compared with the S-(-) isomer, dextromethorphan has lower dopamine agonist activity. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (351.8 mM), Sonication is recommended. H2O : 100 mg/mL (351.8 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (14.07 mM), Sonication is recommended.
|
| Keywords | R-Pramipexole Dihydrochloride | R-Pramipexole | Pramipexole Dihydrochloride | Pramipexole | KNS-760704 Dihydrochloride | KNS760704 Dihydrochloride | KNS-760704 | KNS760704 | KNS 760704 Dihydrochloride | KNS 760704 | Inhibitor | inhibit | DopamineReceptor | Dopamine Receptor | Dopamine | Dexpramipexole dihydrochloride | Dexpramipexole | (R)-Pramipexole |
| Inhibitors Related | Trifluoperazine dihydrochloride | Clozapine N-Oxide | Mirtazapine | Hexamethonium Bromide | Butyrophenone | Octopamine hydrochloride | L-DOPA | Creatine | Dopamine hydrochloride | Oxolinic acid | Mianserin hydrochloride | Doxepin hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Anti-Parkinson's Disease Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Neuroprotective Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library |