| Name | Didanosine |
| Description | Didanosine (ddI) is a nucleoside reverse transcriptase inhibitor analog of adenosine (IC50: 0.49 μM). |
| In vivo | In cultured human muscle cells, Didanosine induced accumulation of cytoplasmic lipid droplets, increased lactate production, and decreased SDH (part of complex II) and COX (complex IV) activity. In HIV target cells, Didanosine was converted to its active form, deoxyadenosine-5'-triphosphate (ddATP). In dissociated DRG cells in culture, Didanosine dose-dependently induced reductions in the number of neurites, the length of each neurite in the longest neurite, and the total length of the neurite. In dissociated DRG neurons, Didanosine dose-dependently induced neurite retraction or axon loss, suggesting that desipramine is useful in the development of peripheral neuropathy. In cultured human TK6 lymphoblastoid cells, Didanosine induced mutagenicity of the thymidine kinase gene induced by zidovudine. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (8.47 mM), Sonication is recommended.
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 70 mg/mL (296.32 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | ReverseTranscriptase | Reverse Transcriptase | orally active | Inhibitor | inhibit | IEC-6 cells | Human immunodeficiency virus | HIVProtease | HIV Protease | HIV | Didanosine | apoptosis | antiretroviral |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Emtricitabine | Dolutegravir intermediate-1 | Dimethyl fumarate | Lamivudine | Chloroquine phosphate | Valproic Acid | (-)-Epigallocatechin Gallate | Decanedioic acid | Dextran sulfate sodium salt (MW 5000) | Tenofovir |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Drug-induced Liver Injury (DILI) Compound Library | Anti-Viral Compound Library | Drug Repurposing Compound Library | Drug-Fragment Library | Inhibitor Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Bitter Compound library | Bioactive Compounds Library Max | Preclinical Compound Library |
United States
