| Name | Dihomo-γ-linolenic acid |
| Description | Dihomo-γ-linolenic acid (DGLA) is a fatty acid widely found in plants with antitumor and antiproliferative effects, inhibits the growth of xenograft tumor cells, and can be used in the study of inflammation-related diseases such as rheumatoid arthritis, atherosclerosis, and atopic dermatitis. |
| In vitro | In THP-1 macrophages, Dihomo-γ-linolenic acid (50 μM; 24 hours) attenuates IFN-γ-induced phosphorylation of STAT1 at serine 727[2]. |
| In vivo | In 48 four-week-old female nude mice, administration of 8 mg per mouse via oral gavage twice a week for 35 days suppressed the metastatic potential of D5D-KD tumors[3]. |
| Storage | store at low temperature,keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (10.77 mM), Sonication is recommended. Ethanol : 100 mg/mL (326.29 mM), Sonication is recommended. DMSO : 140 mg/mL (456.8 mM), Sonication is recommended.
|
| Keywords | EndogenousMetabolite | Endogenous Metabolite | Dihomo-γ-linolenic acid | Dihomoγlinolenic acid | Dihomo-r-linolenic acid | Dihomo-gamma-linolenic acid | Dihomo γ linolenic acid |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium |
| Related Compound Libraries | Food Sourced Compound Library | Bioactive Compound Library | ReFRAME Related Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Bioactive Lipid Compound Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |