| Name | Dihydromyricetin |
| Description | Dihydromyricetin (Ampelopsin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. Dihydromyricetin is a potent inhibitor of dihydropyrimidinase with an IC50 of 48 μM. Dihydromyricetin can activate autophagy by inhibiting mTOR signaling. |
| In vitro | Intraperitoneal injection of 1 mg/kg Dihydromyricetin in rats neutralizes the symptoms of acute alcohol intoxication and eliminates signs of increased tolerance, heightened anxiety, and susceptibility to convulsions. The LD50 for intraperitoneal injection in mice is 1.41 g/kg. |
| In vivo | Dihydromyricetin (1 μM), as an innovative anti-alcohol intoxication agent, antagonizes acute ethanol-induced enhancements in GABA(A)Rs, as well as increases in GABA(A)R plasticity and expression of the GABA(A)R α4 subunit in the hippocampus and cultured neurons due to ethanol exposure/withdrawal. Additionally, Dihydromyricetin effectively scavenges DPPH radicals and inhibits the increase in lipid peroxidation catalyzed by FeSO4 and ethylenediaminetetraacetic acid in the linoleic acid system. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 60 mg/mL (187.35 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (15.61 mM), Sonication is recommended.
DMSO : 242 mg/mL (755.66 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | RNASynthesis | RNA Synthesis | mTOR | Mammalian target of Rapamycin | Inhibitor | inhibit | InfluenzaVirus | Influenza Virus | GABAReceptor | GABAR | GABA Receptor | DNASynthesis | DNA/RNA Synthesis | DNA Synthesis | Dihydromyricetin | Autophagy |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Tamoxifen | Guanidine hydrochloride | Hydroxychloroquine | Penicillin G sodium salt | Paeonol | Thymidine | Naringin | Alginic acid | Sildenafil citrate |
| Related Compound Libraries | Flavonoid Natural Product Library | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Traditional Chinese Medicine Monomer Library | Membrane Protein-targeted Compound Library | Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Anti-virus Traditional Chinese Medicine Monomer Library | Ion Channel Targeted Library | Ancient Chinese Classical Formulas Compound Library |
United States
