| Name | Diminazene Aceturate |
| Description | Diminazene is a trypanocidal agent. |
| In vitro | Administering 7 mg/kg, i.m. of Diminazene aceturate effectively clears parasites from the bloodstream of infected dogs. An initial treatment dose of 3.5 mg/kg of Diminazene aceturate significantly alleviates T. evansi infection in horses and mules, with parasites being eliminated from the peripheral blood within 1-7 days and 1-14 days, respectively. |
| In vivo | Transport of [3H] diminazene is substantially inhibited by pentamidine and adenosine, with Ki values of 0.21 μM and 0.25 μM, respectively. Notably, [3H] diminazene accumulates in yeast cells expressing TbAT1 at a rate of 0.0083 pmol/10^7 cells/s when treated with 2.5 μM of the radioactive compound, and this accumulation is completely suppressed by 1 mM of unlabeled Diminazene Aceturate. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (1.94 mM), Sonication is recommended.
H2O : 92 mg/mL (178.46 mM), Sonication is recommended.
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 1 mg/mL (1.94 mM), Sonication is recommended.
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| Keywords | Trypsin-1 | SerineProtease | Serine Protease | QacR | Peroxiredoxin-5 | Parasite | Inhibitor | inhibit | Diminazene diaceturate | Diminazene Aceturate | Diminazene | Angiotensin-converting Enzyme (ACE) |
| Inhibitors Related | Gum arabic | Kojic acid | Hydroxychloroquine | Metronidazole | Avermectin B1a | Imidazole | 2-Amino-2-methyl-1-propanol | Doxycycline | Fenpyroximate | Proteinase K | Methylene Blue trihydrate | Captopril |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Anti-Parasitic Compound Library | Bioactive Compound Library | Approved Drug Library | Protease Inhibitor Library | Drug Repurposing Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library | Anti-COVID-19 Compound Library | Anti-Hypertension Compound Library |
United States
