| Name | Diphyllin |
| Description | Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling. |
| In vitro | The in vitro inhibitory effects of these compounds were evaluated on the production of nitric oxide (NO) and cytokines (tumor necrosis factor (TNF)-alpha and interleukin (IL)-12), from LPS/IFN-gamma activated murine peritoneal macrophages. The results indicated that the 50% inhibition concentration (IC(50)) values of NO production from activated peritoneal macrophages by compounds 1-4 were 100, 25, 12.5 and 50 microM, respectively. In parallel, these dilutions were approximately inhibited in a similar manner to that observed for cytokines (TNF-alpha, and IL-12) production. On the other hand, at 100 microM concentration compounds 3 and 4 showed 50% inhibition of NO production from peritoneal macrophages that had been pre-activated with LPS/IFN-gamma for 24h, whereas compounds 1 and 2 inhibited only about 20 and 10%, respectively. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.63 mM), Sonication is recommended.
DMSO : 3.81 mg/mL (10.02 mM), Sonication is recommended.
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| Keywords | Wnt/β-catenin | VSV | virus | Vesicular stomatitis virus (VSV) | Vacuolar type H+-ATPase | Protonpump | Proton Pump | lignan | Inhibitor | inhibit | InfluenzaVirus | Influenza Virus | influenza | Human immunodeficiency virus | HIVProtease | HIV-1 | HIV Protease | HIV | Diphyllin | cytotoxicity | c-Myc | ATPase | arylnaphthalene | antiviral |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Emtricitabine | Dimethyl fumarate | Lamivudine | Curcumin | Valproic Acid | (-)-Epigallocatechin Gallate | Decanedioic acid | Dextran sulfate sodium salt (MW 5000) | Benzimidazole | β-Cyclodextrin |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Miao medicine Compound Library | Anti-Viral Compound Library | Inhibitor Library | Natural Product Library for HTS | Anti-infective Natural Product Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Anti-Cancer Active Compound Library |
United States
