| Name | Dipyrithione |
| Description | Dipyrithione appears to have novel cytotoxicity and potent broad-spectrum antitumor activity |
| Cell Research | Used MTT assays and trypan blue staining to test the viability of cancer cell lines. Hoechst 33258 and DAPI staining were used to observe cell apoptosis. Cell-cycle percentages were analyzed by flow cytometry. Apoptosis was assayed using caspase-3 and poly (ADP-ribose) polymerase (PARP) combined with Western blotting. Student's t-test was used for statistical analysis[1]. |
| In vitro | Dipyrithione(PTS2) inhibited proliferation in four cancer cell lines in a dose-dependent manner. Treated cells showed shrinkage, irregular fragments, condensed and dispersed blue fluorescent particles compared with control cells. PTS2 induced cycle-arrest and death. Cleavage of caspase-9, caspase-3, and PARP were detected in PTS2-treated cells. Antitumor activity of PTS2 was more effective against widely used cancer drugs and its precursor[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 2.53 mg/mL (10.03 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (3.96 mM), Sonication is recommended.
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| Keywords | Inhibitor | inhibit | G1 phase | Fungal | Dipyrithione | dermatophytosis | Bacterial | Apoptosis | anti-tumor | antiproliferative | anti-inflammatory | antifungal |
| Inhibitors Related | Neomycin sulfate | Calcium Propionate | Aceglutamide | D(+)-Raffinose pentahydrate | Benzyl propionate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Formamide | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate |
| Related Compound Libraries | Pesticide Compound Library | Bioactive Compound Library | Anti-Fungal Compound Library | Drug Repurposing Compound Library | Anti-Bacterial Compound Library | Anti-Cancer Approved Drug Library | Cosmetic Ingredient Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Infection Compound Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
United States
