| Name | DJ-V-159 |
| Description | DJ-V-159 is a GPRC6A agonist, targeting the G protein-coupled receptor family C group 6 member A (GPRC6A). |
| In vitro | DJ-V159 activates ERK in HEK-293 cells transfected with GPRC6A but not in non-transfected HEK-293 cells, with potency similar to L-Arg. Additionally, DJ-V159 dose-dependently stimulates cAMP production in GPRC6A-expressing HEK-293 cells at 0.2 nM concentrations in the media. DJ-V159 also stimulates insulin secretion in mouse beta-cell MIN-6 cells, with an insulin stimulation index (SI) similar to Ocn, a known ligand of GPRC6A [1]. |
| In vivo | DJ-V-159 (10 mg/kg, i.p.) reduces blood glucose levels in wild-type mice at 60 and 90 minutes, whereas the vehicle (95% PEG + 5% DMSO) has no effect on blood glucose. DJ-V-159 (10 mg/kg, i.p.) reduces blood glucose levels in wild-type mice by 43.6% and 41.9% at 60 and 90 minutes, respectively. The mice tolerated this short-term exposure to DJ-V-159 without any overt side-effects. DJ-V-159, however, is almost in or on the boundary of the Lipinski's Rule of Five [1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 5.03 mg/mL (10.01 mM), Sonication is recommended.
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| Keywords | Inhibitor | inhibit | GPRC6A | DJ-V-159 | DJV159 | DJ-V 159 | DJ V 159 | AndrogenReceptor | Androgen Receptor |
| Inhibitors Related | Dehydroisoandrosterone 3-acetate | Monomethyl fumarate | 2-Ethylhexyl trans-4-methoxycinnamate | S-23 | Pamoic acid disodium | Enzalutamide | Benzyl nicotinate | Testosterone propionate | Allura Red AC | Sunset Yellow FCF | 2-sec-Butylphenol | Flutamide |
| Related Compound Libraries | Nuclear Receptor Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Prostate Cancer Compound Library | NO PAINS Compound Library | Endocrinology-Hormone Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Fluorochemical Library | GPCR Compound Library | Anti-Cancer Compound Library | Transcription Factor-Targeted Compound Library |
United States
