| Name | DL-Sulforaphane N-acetyl-L-cysteine |
| Description | DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC), a metabolite of sulforaphane, induces apoptosis through down-regulation of α-microtubulin and phosphorylation of ERK1/2-mediated Stathmin-1, and up-regulation of Hsp70 through phosphorylation of ERK1/2 in non-small-cell lung cancer (NSCLC). |
| In vitro | In studies on U87MG and U373MG cells, treatment with DL-Sulforaphane N-acetyl-L-cysteine (30 μM) for 24 hours resulted in cell cycle analysis showing drug-induced G2/M phase arrest, along with the initiation of apoptosis. In the same cell lines, Western blot analysis revealed that DL-Sulforaphane N-acetyl-L-cysteine, within a concentration range of 10 to 50 μM, activated ERK1/2 (Thr202/Tyr204), downregulated α-tubulin, and induced autophagy in a dose-dependent manner. Additionally, cell viability assays showed that DL-Sulforaphane N-acetyl-L-cysteine, within a concentration range of 0 to 90 μM, decreased the viability of HA cells, U87MG cells, and U373MG cells in a dose-dependent manner, with IC50 values of 60.08 μM, 35.20 μM, and 39.11 μM, respectively[1]. |
| In vivo | In the HDAC inhibition model, DL-Sulforaphane N-acetyl-L-cysteine (10 μmol, oral gavage, single dose, 6-hour treatment) significantly inhibited histone deacetylase (HDAC) activity in the colon mucosa of mice[2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 8 mg/mL (23.5 mM), Sonication is recommended.
PBS (pH 7.2) : 8 mg/mL (23.5 mM), Sonication is recommended.
Ethanol : 4 mg/mL (11.75 mM), Sonication is recommended.
DMF : 8 mg/mL (23.5 mM), Sonication is recommended.
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| Keywords | DL-Sulforaphane N-acetyl-L-cysteine | DLSulforaphane NacetylLcysteine | DL Sulforaphane N acetyl L cysteine |
| Inhibitors Related | Ethoxyquin | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Manganese chloride (tetrahydrate) | Formamide | Gluconate Calcium | Alginic acid | Sildenafil citrate |
United States
