| Name | Dopexamine hydrochloride |
| Description | Dopexamine hydrochloride (FPL60278AR) is a β2-adrenergic receptor agonist. Dopexamine can attenuate the inflammatory response and protect against organ injury in the absence of significant effects on hemodynamics or regional microvascular flow. |
| In vitro | Dopexamine, a dopamine analogue, stimulates β-adrenergic as well as dopamine 1 and 2 receptors, offering vasodilatory effects. It effectively mitigates the systemic inflammatory response triggered by endotoxin, including the release of cytokines, the expression of endothelial adhesion molecules, and oxidative stress, without significantly affecting systemic hemodynamics, such as blood pressure or stroke volume. Additionally, dopexamine possesses agonist activity at β2 and dopaminergic receptors, and at dosages that do not impact global hemodynamics or regional microvascular flow, it can diminish tissue leukocyte infiltration and confer protection against organ damage. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.33 mM), Sonication is recommended.
DMSO : 10 mg/mL (23.29 mM), Sonication is recommended.
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| Keywords | β2-adrenergic receptor | β2 adrenergic receptor | Inhibitor | inhibit | Dopexamine Hydrochloride | Dopexamine | Beta Receptor | AdrenergicReceptor | Adrenergic Receptor |
| Inhibitors Related | Trifluoperazine dihydrochloride | Mirtazapine | Octopamine hydrochloride | Gemfibrozil | Buflomedil hydrochloride | Dexmedetomidine hydrochloride | Isoprenaline hydrochloride | D-Mannitol | Mianserin hydrochloride | Trazodone hydrochloride | Atenolol | Doxepin hydrochloride |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Cardiovascular Disease Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |
United States
