Dotinurad Nitroso Impurity 69
WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com
Product Number: D081069
English Name: Dotinurad Nitroso Impurity 69
English Alias: 3-nitroso-2,3-dihydrobenzo[d]thiazole
CAS Number: None
Molecular Formula: C₇H₆N₂OS
Molecular Weight: 166.20
As a nitroso impurity of dotinurad, the research advantages of this compound lie in:
Analyzing the by-product formation mechanism of nitrosation reactions during dotinurad synthesis to optimize processes for controlling nitroso impurity generation;
Serving as a nitroso-class reference standard to provide a standard substance for detecting nitroso impurities in drugs, assisting in evaluating drug safety (nitroso compounds may have potential carcinogenicity);
Helping study the impact of nitroso structures on drug stability and toxicological properties to provide a scientific basis for formulating impurity control strategies.
Drug Development: Used as an impurity reference standard to identify and quantify nitroso impurities in dotinurad preparations, evaluating the purity of APIs and formulations;
Quality Control: Acting as a standard substance to validate the sensitivity of detection methods (e.g., HPLC or LC-MS), ensuring nitroso impurity content meets ICH guideline requirements during production;
Toxicological Research: Assisting in evaluating the potential genotoxicity of nitroso impurities to provide data support for drug safety evaluation.
Dotinurad, a uric acid transporter inhibitor, is used for treating gout. Due to the potential carcinogenic risk of nitroso compounds (such as N-nitrosamines), drug regulatory authorities worldwide have put forward strict control requirements for nitroso impurities in drugs. Dotinurad Nitroso Impurity 69, as an impurity containing a nitroso structure, may be generated during dotinurad synthesis or storage, making research on it a key link in drug quality control and safety assessment.
Current research focuses on:
Synthesis Methods: Developing high-purity synthesis processes for 3-nitroso-2,3-dihydrobenzo[d]thiazole to meet the needs of toxicological research and quality control;
Detection Technologies: Establishing trace detection methods for nitroso impurities (detection limits ppb level) using ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and other technologies;
Toxicological Evaluation: Studying the potential mutagenicity and carcinogenicity of this impurity through in vitro Ames tests and animal models;
NOTE！
We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!
WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com
NEW IN STOCK!
The Molcoo Laboratory added drug impurity reference standards, including Baricitinib, Piperazine, Benzylpenicillin, Tranilast and multiple N-Nitroso drug impurities! Now available for immediate delivery!
China
