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ChemicalBook Product Catalog DS-6930

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DS-6930 NEW

$3970.00 25mg

$5550.00 50mg

$7490.00 100mg

Min. Order
Purity
Cas No1242328-82-0
Supply Ability10g
Update time2026-04-13

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP2Y

United States

United States

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Chemical Properties

Product Name	DS-6930
CAS No	1242328-82-0
EC-No
Min. Order
Purity
Supply Ability	10g
Release date	2026/04/13

Product Introduction

Bioactivity

Name	DS-6930
Description	DS-6930 is an potent and selective PPAR γ Agonists with EC50 of 41 nM. DS-6930 can effectively reduce plasma glucose (PG) level, and has less PPARγ-related adverse effects compared with Rosiglitazone. DS-6930 has research value in diabetes.
In vitro	DS-6930 demonstrates high in vitro potency with intermediate PPARγ agonist activity (EC50 = 41 nM, Emax = 68%) and exhibits high selectivity for PPARα and PPARδ (13% activation and no activation at 10 μM, respectively) [1]. DS-6930 (10-100 μM) also shows reduced cell toxicity at 100 μM [1].
In vivo	DS-6930 administered orally at dosages ranging from 0.1 to 3 mg/kg for three weeks results in a dose-dependent decrease in plasma glucose (PG) levels in rats, with no significant impact on liver enzyme activities and relative heart weight after a higher dosage range of 100 to 1000 mg/kg for four weeks, indicating safety at studied doses. Additionally, pharmacokinetic analysis reveals DS-6930 achieves a maximum concentration (Cmax) of 0.0792 μg/mL and an area under the curve (AUC) of 0.861 h μg/mL 1.8 hours post-administration at a dose of 0.3 mg/kg by day 22 in rats. In cynomolgus monkeys, oral administration shows a Cmax of up to 2.25 μg/mL, a half-life (T1/2) of 13.5 hours, and an AUC of 23.5 h μg/mL at a 3 mg/kg dose, alongside excellent bioavailability (F=89%), total body clearance (CL=2.06 mL/min/kg), and steady-state distribution volume (Vss=0.36 L/kg) following intravenous administration of 1 mg/kg. A specific study in male ZDF rats demonstrates a 47% reduction in PG levels with a 0.3 mg/kg daily oral dose over three weeks, further underscoring DS-6930's efficacy and pharmacokinetic properties in animal models.
Storage	Shipping with blue ice/Shipping at ambient temperature.
Inhibitors Related	PHYTOL \| Rosiglitazone \| Retinoic acid \| Daidzein \| Fenofibrate \| Magnesium acetate tetrahydrate \| Maltitol \| Naringenin \| 2,3-Butanediol \| NPC 15199 \| Icariin \| Cloxiquine

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