| Name | DS-7423 |
| Description | DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM and 34.9 nM for PI3Kα and mTOR, respectively, and exhibits anti-tumor activity[1][2]. It increases TP53 expression, the level of p-TP53 on Ser-46, and induces apoptosis-related TP53 target genes (TP53AIP1 and PUMA) in OCCC cells[1]. DS-7423 also inhibits other isoforms of class I PI3K with IC50 values of 1,143 nM for PI3Kβ, 249 nM for PI3Kγ, and 262 nM for PI3Kδ[2].
[1]. Katsutoshi Oda, et al. Characterization of TP53 and PI3K signaling pathways as molecular targets in gynecologic malignancies. J Obstet Gynaecol Res. 2016 Jul;42(7):757-62. [2]. Tomoko Kashiyama, et al. Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423. PLoS One. 2014 Feb 4;9(2):e87220. |
| In vitro | DS-7423 elevates TP53 expression, enhances p-TP53 on Ser-46 phosphorylation, and stimulates apoptosis-related TP53 target genes (TP53AIP1 and PUMA) in OCCC cells[1]. Additionally, it selectively inhibits class I PI3K isoforms with varying IC50 values: PI3Kβ at 1,143 nM, PI3Kγ at 249 nM, and PI3Kδ at 262 nM[2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 65 mg/mL (124.88 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (3.84 mM), Sonication is recommended.
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| Keywords | TP53AIP1 | TP53 | PUMA | PI3Kα | PI3K | Phosphoinositide 3-kinase | OCCC | mTOR | Mammalian target of Rapamycin | Inhibitor | inhibit | DS-7423 | DS7423 | DS 7423 |
| Inhibitors Related | Musk ketone | Stearamide | L-Leucine | Myricetin | Creatine monohydrate | Hyaluronic acid | L-Proline | Isoprenaline hydrochloride | Metformin | Methyl eugenol | Quercetin | Dihydromyricetin |
| Related Compound Libraries | Anti-Lung Cancer Compound Library | Bioactive Compound Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Liver Cancer Compound Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
United States
