| Name | Ebselen |
| Description | Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced by reactive oxygen species (ROS). In addition, this agent inhibits the activity of a variety of enzymes including nitric oxide synthase (NOS), 5-lipoxygenase, cyclooxygenase, protein kinase C (PKC), NADPH oxidase and gastric H+/K+-ATPase. Furthermore, ebselen may be neuroprotective due to its ability to neutralize free radicals upon NMDA receptor activation thus, reducing lipoperoxidation mediated by glutamate-induced excitotoxicity. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 40 mg/mL (145.89 mM), Sonication is recommended.
H2O : Insoluble
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (7.29 mM), Sonication is recommended.
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| Keywords | voltage-dependent | VirusProtease | Virus Protease | VDCC | SPI1005 | SPI 1005 | QSOX1 | PZ51 | PZ 51 | Phosphatase | peroxidase | Mpro | monophosphatase | mimetic | inositol | Inhibitor | inhibit | IMPase | Human immunodeficiency virus | HIVProtease | HIV Protease | HIV | glutathione | Ebselen | COX | COVID-19 | CCG39161 | CCG 39161 | CalciumChannel | Calcium Channel | Ca2+ channels | Ca channels | C145 | blood-brain | barrier |
| Inhibitors Related | Stavudine | 5-Fluorouracil | 2,4,6-Tri-tert-butylphenol | Emtricitabine | Phenytoin sodium | Acetaminophen | Lamivudine | Thymidine | L-Ascorbic acid sodium salt | Trometamol | Dextran sulfate sodium salt (MW 5000) | Magnesium Chloride Hexahydrate |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Anti-Viral Compound Library | Drug Repurposing Compound Library | Neuroprotective Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |
United States
