| Name | Echinatin |
| Description | Echinatin (Retrochalcone) is extracted from licorice and is a natural chalcone. Echinatin has a wide range of biological activities including hepatoprotective, anti-inflammatory, anti-bacterial infections, and attenuates lung damage. |
| In vitro | METHODS: Esophageal squamous cell carcinoma cells KYSE30 and KYSE270 were treated with Echinatin (10-40 µM) for 1-5 days and cell viability was measured by CCK-8 assay.
RESULTS: Echinatin significantly inhibited cell proliferation in a dose- and time-dependent manner. [1]
METHODS: Human osteosarcoma cells 143B and MG63 were treated with Echinatin (30-50 µM) for 24 h. Cell cycle was measured by Flow cytometry.
RESULTS: Echinatin significantly increased the percentage of osteosarcoma cells in the S phase of the cell cycle. [2] |
| In vivo | METHODS: To test the antitumor activity in vivo, Echinatin (20-50 mg/kg) was administered by gavage to nude mice bearing KYSE270 xenografts every two days for 14 days.
RESULTS: Tumor load was significantly suppressed, with a 57% and 48% reduction in the groups treated with 20 and 50 mg/kg Echinatin, respectively.Echinatin inhibited the AKT/mTOR pathway, as evidenced by a reduction in the expression levels of p-AKT and p-mTOR. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4.9 mg/mL (18.13 mM), Solution.
Chloroform : Soluble
DMSO : 20 mg/mL (74 mM), Sonication is recommended.
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| Keywords | Inhibitor | inhibit | Freeradicalscavengers | Free radical scavengers | Echinatin |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Tamoxifen | Urea | Guanidine hydrochloride | Hydroxychloroquine | Metronidazole | Formamide | Paeonol | Naringin | Alginic acid |
| Related Compound Libraries | Flavonoid Natural Product Library | Selected Plant-Sourced Compound Library | Miao medicine Compound Library | Natural Product Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Anti-infective Natural Product Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library |
United States
