| Name | EG01377 2HCl |
| Description | EG01377 2HCl is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) with a Kd value of 1.32 μM and an IC50 value of 609 nM for both EG01377 2HCl against NRP1-a1 and NRP1-b1.EG01377 exhibits anti-angiogenic, antimigratory and antitumor activities. |
| In vitro | EG0 1377 2HCl (30 μM) effectively diminishes HUVEC cell migration induced by VEGFA. Additionally, EG01377 2HCl leads to reductions in network area, length, and branching points.[1]
EG0 1377 2HCl (3-30 μM; 30 minutes) inhibits vascular endothelial growth factor A (VEGF-A) stimulated tyrosine phosphorylation of VEGF-R2/KDR with an IC50 of 30 μM.[1]
EG0 1377 2HCl (30 μM; 5 days) can delay the VEGF-induced wound closure.[1]
EG0 1377 2HCl diminishes VEGF-triggered angiogenesis. Moreover, when combined with VEGFA, EG01377 2HCl curtails spheroid outgrowth of A375P (malignant melanoma) cells.[1]
EG0 1377 2HCl (500 nM; 2 h) blocks the production of transforming growth factor beta (TGFβ) by Nrp1+ regulatory T-cell SMAD3/AKT (Tregs) in the presence of tumor cell-derived factors.[1] |
| In vivo | EG0 1377 2HCl (2 mg/kg; i.v.; BABL/c female mice) possesses a half-life of 4.29 hours, allowing for once-a-day dosing to be maintained in mice.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 180 mg/mL (272.89 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (7.58 mM), Sonication is recommended.
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| Keywords | neuropilin-1(NRP1) | EG01377 2HCl | EG-01377 | EG01377 | EG 01377 | ComplementSystem | Complement System |
| Inhibitors Related | Iptacopan hydrochloride | Iptacopan | BCX 1470 hydrochloride | Complement C5-IN-1 | Avacopan | ADH-503 | CP-289 | Dexamethasone acetate | Dexamethasone | Cyclosporin A | Dextran sulfate sodium salt (MW 5000) | 3-Phenoxybenzaldehyde |
| Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
United States
