Basic information Safety Related Supplier

ChemicalBook Product Catalog Elimusertib

1/1

Elimusertib NEW

$31.00 1mg

$72.00 5mg

$113.00 10mg

Min. Order
Purity99.75%
Cas No1876467-74-1
Supply Ability10g
Update time2026-04-14

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP6Y

United States

United States

show more

Enterprise Verified

Business Bank account Basic Contact Infomation Business Address Trade Company

Chemical Properties

Product Name	Elimusertib
CAS No	1876467-74-1
EC-No
Min. Order
Purity	99.75%
Supply Ability	10g
Release date	2026/04/14

Product Introduction

Bioactivity

Name	Elimusertib
Description	Elimusertib (BAY-1895344) is a potent, highly selective, and orally available ATR inhibitor with an IC50 of 7 nM, demonstrating significant anti-tumor efficacy as a monotherapy and strong combination potential with targeted alpha therapy Radium-223 dichloride.
In vivo	The novel selective ATR kinase inhibitor Elimusertib on tumor cell growth and viability.Potent antiproliferative activity was demonstrated in a broad spectrum of human tumor cell lines.Elimusertib exhibited strong monotherapy efficacy in cancer xenograft models that carry DNA damage repair deficiencies.The combination of Elimusertib with DNA damage-inducing chemotherapy or external beam radiotherapy (EBRT) showed synergistic antitumor activity.Combination treatment with Elimusertib and DDR inhibitors achieved strong synergistic antiproliferative activity in vitro, and combined inhibition of ATR and PARP signaling using olaparib demonstrated synergistic antitumor activity in vivo Furthermore, the combination of Elimusertib with the novel, nonsteroidal androgen receptor antagonist darolutamide resulted in significantly improved antitumor efficacy compared with respective single-agent treatments in hormone-dependent prostate cancer,and addition of EBRT resulted in even further enhanced antitumor efficacy[1].
Storage	Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO : 22.5 mg/mL (59.93 mM), Sonication is recommended.
Keywords	tumors \| stress \| solid \| response \| replication \| repair \| lymphomas \| instability \| Inhibitor \| inhibit \| genomic \| Elimusertib \| DNA \| damage \| BAY1895344 \| BAY 1895344 \| ATR \| ATM/ATR \| ATM and RAD3 related \| ATM \| Ataxia telangiectasia mutated
Inhibitors Related	CP-466722 \| Camonsertib \| GJ071 oxalate \| ART0380 \| VE-821 \| GJ103 sodium salt \| KU60019 \| AZD-7648 \| (Z)-Mirin \| Torin 2 \| NU6027 \| Schisandrin B
Related Compound Libraries	Highly Selective Inhibitor Library \| Bioactive Compound Library \| HIF-1 Signaling Pathway Compound Library \| Kinase Inhibitor Library \| Anti-Cancer Clinical Compound Library \| Drug Repurposing Compound Library \| Inhibitor Library \| Immunology/Inflammation Compound Library \| Anti-Aging Compound Library \| Bioactive Compounds Library Max \| Anti-Cancer Drug Library \| Anti-Cancer Active Compound Library

show more

Company Profile Introduction

You may like

Recommended supplier

Send Inquriy