| Name | Ellagic acid |
| Description | Ellagic acid (Gallogen), a thickened tetracyclic natural product, is a potent CK2 inhibitor (IC50=40 nM; Ki=20 nM) with ATP-competitive properties. Ellagic acid is an antioxidant and also possesses antiproliferative activity. |
| In vitro | METHODS: Human pancreatic cancer cell lines PANC-1, AsPC-1 and MIA PaCA-2 were treated with Ellagic acid (10-1000 µM) for 24-72 h. Cell viability was measured by MTT assay.
RESULTS: The proliferation of PANC-1 was inhibited by the addition of 10 µM Ellagic acid in a dose-dependent manner. The proliferation of AsPC-1 was inhibited by the addition of 100 µM Ellagic acid, while the proliferation of MIA PaCA-2 was inhibited only by the addition of 1000 µM Ellagic acid. [1]
METHODS: Human lung cancer cells A549 were treated with Ellagic acid (5-20 µM) for 48 h, and the expression levels of target proteins were detected by Western Blot.
RESULTS: Ellagic acid treatment significantly down-regulated the phosphorylation of PI3K and Akt in a dose-dependent manner. [2] |
| In vivo | METHODS: To investigate the hepatoprotective effects on alcohol-induced liver disease (ALD), Ellagic acid (50-100 mg/kg suspended in 0.5% CMC-Na) was administered by gavage once daily for four weeks to ICR mice receiving 50% (v/v) alcohol orally daily.
RESULTS: Ellagic acid attenuated oxidative stress, inflammatory response, steatosis and gut microbiota dysbiosis in ALD mice. [3] |
| Storage | 02 | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 3.03 mg/mL (10.03 mM), Sonication is recommended.
10% DMSO+90% Saline : 0.15 mg/mL (0.5 mM), Solution.
|
| Keywords | Topo I | Syk | Smoothened | ReactiveOxygenSpecies | Reactive Oxygen Species | PKC | PKA | Inhibitor | inhibit | Hedgehog | EndogenousMetabolite | Endogenous Metabolite | Ellagic acid | CK2 | CaseinKinase | Casein Kinase | CarbonicAnhydrase | Carbonic anhydrase |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Ethyl linoleate | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Miao medicine Compound Library | Drug Repurposing Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library for HTS | Cosmetic Ingredient Compound Library | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Food as Medicine Compound Library |
United States
