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ChemicalBook Product Catalog ENMD-1198

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ENMD-1198 NEW

$1520.00 25mg

$1980.00 50mg

$2500.00 100mg

Min. Order
Purity
Cas No864668-87-1
Supply Ability10g
Update time2026-04-13

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP2Y

United States

United States

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Chemical Properties

Product Name	ENMD-1198
CAS No	864668-87-1
EC-No
Min. Order
Purity
Supply Ability	10g
Release date	2026/04/13

Product Introduction

Bioactivity

Name	ENMD-1198
Description	ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.
In vitro	ENMD-1198 inhibits the proliferation of endothelial cell HMEC-1 and BMH29L (IC50: 0.4 μM and 3.8 μM) and it also significantly inhibits capillary tube formation from 0.1 μM and suppresses endothelial cell morphogenesis at 1 μM. ENMD-1198 inhibits endothelial cell motility and endothelial cell migration and inhibits MDA-BO2 cancer cell viability (IC50: approximately 0.8 μM). ENMD-1198 also inhibits the phosphorylation of MAPK/Erk, PI-3K/Akt, and FAK. ENMD-1198 (0.5 μM) inhibits the formation of capillary tubes in HMEC-1 cells. Moreover, ENMD-1198 at the IC50 for cell proliferation causes a significant decrease in VEGFR-2 expression both in the presence and in the absence of serum. ENMD-1198 rapidly causes extensive microtubule depolymerization and accumulation of actin stress fibers and large focal adhesions [1]. ENMD-1198 has both an antiangiogenic effect and a vascular disruptive effect in vitro. ENMD-1198 reduces the viability of RAW264.7 osteoclast precursor cells and inhibits PTHrP-stimulated bone resorption. ENMD-1198 shows inhibitory activity against RAW264 (IC50: approximately 0.4 μM) and is shown to be 4 times more potent than 2ME2 (IC50 appro 1.6 μM) [2]. The activation of HIF-1α and STAT3 is dramatically reduced by ENMD-1198, which leads to lower VEGF mRNA expression. In addition, the tumor cell migratory and invasive properties are obviously inhibited [3].
In vivo	ENMD-1198 treatment protects the bone against tumor-induced osteolysis in vivo [2]. ENMD-1198 (200 mg/kg/d, peroral gavage)-based combination treatments decrease tumor burden but do not eradicate the tumor in mice. ENMD-1198 (200 mg/kg/day, p.o.) leads to a significant reduction in tumor growth, tumor vascularization, and numbers of proliferating tumor cells [3].
Storage	Shipping with blue ice/Shipping at ambient temperature.
Keywords	STAT3 \| IRC-110160 \| IRC110160 \| HIF-1α \| ENMD-1198 \| ENMD1198 \| ENMD119 \| ENMD 119
Inhibitors Related	Flubendazole \| HODHBt \| Dapagliflozin \| Nifuroxazide \| Balsalazide disodium dihydrate \| Glucosamine \| Hydroxycitric acid tripotassium hydrate \| α-Cyclodextrin \| Niclosamide \| Glucosamine hydrochloride \| Methylene Blue trihydrate \| Chloramphenicol

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