| Name | Epiberberine chloride |
| Description | Epiberberine chloride, a natural pro-berberine from Coptis chinensis Franch. is an AChE, BChE, and BACE1 inhibitor with IC50 values of 1.07, 6.03, and 8.55 μM, respectively.Epiberberine chloride has antioxidant effects and inhibits the effects of Ca9-22 and Fa2R. Epiberberine chloride has antioxidant effects, inhibits the motility of Ca9-22 and FaDu cell lines, and can be used to study hyperlipidemia, Alzheimer's disease and diabetes. |
| In vitro | Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease[1]. Epiberberine (0, 12.5, 25, or 50 μM) dose-dependently inhibits cellular triglyceride accumulation in 3T3-L1 adipocytes (IC50: 52.8 μM). Epiberberine (12.5-50 μM) suppresses the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways in the early stage of 3T3-L1 adipocyte differentiation [2]. Epiberberine (0.2, 1, 5 μg/mL) inhibits glucose uptake in HepG2 cells in a concentration-dependent manner [3]. |
| In vivo | Body weight, food consumption, water intake, and urinary output of KK-Ay mice were reduced after being treated with Epiberberine (225 mg/kg, p.o. daily for 40 days). |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Saline : 2 mg/mL (5.38 mM), Sonication is recommended.
DMSO : 20 mg/mL (53.79 mM), Sonication is recommended.
|
| Keywords | β-Secretase | Reactive Oxygen Species | Inhibitor | inhibit | Epiberberine (chloride) | Epiberberine | Cholinesterase (ChE) | Beta-secretase | BACE1 | BACE | Antioxidant | AChR | AChE |
| Inhibitors Related | Ethoxyquin | Kaolin | Allopurinol | Cysteamine hydrochloride | Urethane | Adenine | Ethyl linoleate | Magnesium acetate tetrahydrate | L-Cystine | N,N-Dicyclohexylcarbodiimide | Dimethyl sulfoxide | Dimethyl phthalate |
| Related Compound Libraries | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Alkaloid Natural Product Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library |
United States
