| Name | Eragidomide |
| Description | Dicyclanil is an insect growth regulator with a chemical structure similar to that of cyclopromazine. |
| In vitro | Eragidomide demonstrated potent antiproliferative activity in 10 of 11 cell lines (e.g. NB4, U937, KG-1, MOLM-13, HL60 cells)with much less effect on the cell viability of PBMCs and THLE-2. The antiproliferative effect of Eragidomide is associated with apoptosis induction in all tested AML cell lines except OCI-AML3[1]. |
| In vivo | In NOD/SCID mice, heterogeneous responses to the Eragidomide treatment (2.5mg/kg BID for 4 weeks) were observed. Of 35 AML samples tested, 16 were highly responsive to Eragidomide with >75% reduction of AML engraftment, 10 showed moderate response between 45% and 75% reductions, and 9 showed reductions of <25%. AML is clinically characterized by the accumulation of blasts that are impaired for differentiation and maturation. Eragidomide induced myeloid differentiation of AML blasts in the Eragidomide responders[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 128.75 mg/mL (278.77 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (10.83 mM), Sonication is recommended.
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| Keywords | T-lymphocytes | proteasome-mediated | MolecularGlues | Molecular Glues | Ligands for E3 Ligase | LigandforE3Ligase | Ligand for E3 Ligase | IRF4 | Inhibitor | inhibit | IKZF3 | IKZF1 | Eragidomide | E3 ligase-recruiting Moiety | degradation | CRBN | c-myc | cereblon (CRBN) E3 ligase | Cereblon | CC90009 | CC 90009 | Apoptosis | anti-cancer |
| Inhibitors Related | Stavudine | Aceglutamide | Tamoxifen | Urea | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Dextran sulfate sodium salt (MW 5000) |
| Related Compound Libraries | Apoptosis Compound Library | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
United States
