| Name | ESI-09 |
| Description | ESI-09 is a new-typel noncyclic nucleotide EPAC antagonist.The IC50 values of ESI-09 for EPAC1 and EPAC2 is 3.2 and 1.4 μM, respectively. |
| In vitro | In WT C57BL/6 mice, ESI-09 (10 mg/kg/d, i.p.) prevents SFG Rickettsiosis by inhibiting EPAC1. |
| In vivo | ESI-09 specifically inhibits intracellular EPAC-mediated activation of Rap1 and phosphorylation of Akt, as well as EPAC-mediated secretion in pancreatic β-cells. In pancreatic cancer cells induced by 007-AM, ESI-09 reduces cell adhesion and inhibits cell migration. In Schwann cells stimulated by CPT-cAMP, ESI-09 significantly suppresses cell differentiation and myelination. Additionally, in SC neuronal cultures, ESI-09 notably decreases the number of O1-positive and MBP-positive cells. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 83.33 mg/mL (251.93 mM), Sonication is recommended. Ethanol : 6.6 mg/mL (19.95 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (6.05 mM), Sonication is recommended.
|
| Keywords | VirusProtease | Virus Protease | Inhibitor | inhibit | ESI-09 | ESI09 | ESI 09 | EPAC2 | EPAC1 |
| Inhibitors Related | Rifampicin | Phenytoin sodium | Levofloxacin hydrochloride | Ribavirin | Anthraquinone | L-Lysine | L-Lysine hydrochloride | Ofloxacin | Vidarabine | Thymidine | N4-Acetylcytidine | Danthron |
| Related Compound Libraries | Highly Selective Inhibitor Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Obesity Compound Library | Protease Inhibitor Library | Anti-Viral Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | GPCR Compound Library | Anti-Cancer Compound Library | Anti-Infection Compound Library |