| Name | Ethambutol |
| Description | Ethambutol is an oral anti-tuberculosis drug that inhibits arabinosyl transferase activity, thereby interfering with the synthesis of arabinogalactan and preventing cell wall formation to exert its antibacterial effect; it can also be used for animal models of hyperuricemia and optic neuropathy. |
| In vitro | The MTT or CCK-8 assays showed that Ethambutol (0-50µg/mL) exerted a time-dependent inhibitory effect on cell proliferation in six cell lines, including SW480 and SW620. The IC50 values for different cell lines ranged from 5.37 to 31.54µg/mL over 24-72 hours[1]. In the RGC-5 retinal ganglion cell experiment, after treating the cells with 4mM Ethambutol for 8 hours, flow cytometry and Western blot analysis confirmed a significant increase in cell apoptosis, as well as upregulation of autophagy markers such as PI3C3 and Beclin-1[2]. Additionally, treatment of Mycobacterium smegmatis with 10µg/mL Ethambutol followed by acid hydrolysis combined with HPLC and enzyme activity analysis showed changes in arabinogalactanase activity[3]. |
| In vivo | Ethambutol (250 mg/kg, administered by gavage once daily for 23 days) can induce hyperuricemia and cause pathological damage and inflammatory reactions in the thymus and spleen, manifested by thymic atrophy, fusion of the cortex and medulla, congestion of the splenic sinuses, and hemosiderin deposition [4,5]. In addition, Ethambutol (35 mg/kg/day, orally for 30 days) can induce optic neuropathy, leading to ganglion cell damage, increased retinal ganglion cell (RGC) density, and thickening of the RGC layer [6]. |
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 80 mg/mL (391.56 mM), Sonication is recommended.
H2O : 180 mg/mL (881.01 mM), Sonication is recommended.
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| Keywords | Ethambutol |
| Inhibitors Related | Neomycin sulfate | Ampicillin sodium | Kanamycin sulfate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Metronidazole | Avermectin B1a | Doxycycline | Penicillin G sodium salt | Penicillin G potassium | EDTA copper(II) disodium salt | Ethyl acetoacetate |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Approved Drug Library | Drug-induced Liver Injury (DILI) Compound Library | Toxic Compound Library | Drug Repurposing Compound Library | Anti-Bacterial Compound Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | Anti-Infection Compound Library | NMPA-Approved Drug Library | Human Metabolite Library |
United States
