Etrasimod Impurity 17;567-15-7
WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com
Product Code: E063017
English Name: Etrasimod Impurity 17
English Alias: 2,2'-bis(trifluoromethyl)-1,1'-biphenyl
CAS No.：567-15-7
Molecular Formula: C₁₄H₈F₆
Molecular Weight: 290.20
Purity & Structure: HPLC ≥99.0%, confirmed by X-ray and HRMS.
Stability: Stable for 36 months at -20℃, with <0.1% degradation in toluene.
Regulatory Compliance: Supports ICH Q3C guidelines for residual solvent control.
Impurity Profiling: Detects biphenyl impurities in Etrasimod via HPLC/LC-MS.
Synthesis Monitoring: Tracks biphenyl formation during trifluoromethylation coupling reactions.
Environmental Risk Assessment: Evaluates potential ecological impact of halogenated biphenyls.
This impurity forms from oxidative coupling of trifluoromethylbenzene intermediates. As a persistent organic pollutant, it requires strict control in pharmaceutical manufacturing.
Detection: UPLC-MS/MS with C18 column and gradient elution; LOD: 0.005 ng/mL.
Formation: Catalyzed by transition metals; using chelating agents reduces content by 85%.
Toxicity: OECD tests show low aquatic toxicity, but bioaccumulation potential is being evaluated.
NOTE！
We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!
WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com
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