Etrasimod Impurity 8;380350-42-5
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E-mail: anna@molcoo.com
Product Code: E063008
English Name: Etrasimod Impurity 8
English Alias: ethyl 2-(2-morpholinocyclopent-2-en-1-ylidene)acetate
CAS No.：380350-42-5
Molecular Formula: C₁₃H₁₉NO₃
Molecular Weight: 237.29
High Purity: HPLC ≥99.0%, confirmed by NMR/IR for structural accuracy.
Stability: Shelf life of 24 months at -20℃, with <0.3% degradation in acetonitrile.
Regulatory Compliance: Meets FDA/EMA requirements for impurity reference standards.
Quality Control: Detects Impurity 8 in Etrasimod API via HPLC/LC-MS, ensuring ≤0.1% limit.
Process Optimization: Monitors morpholine cyclization side reactions during synthesis to adjust reaction pH and temperature.
Stability Studies: Evaluates impurity formation under stress conditions (acid/alkali hydrolysis).
Etrasimod, a sphingosine 1-phosphate receptor modulator, may contain this impurity from morpholine ring substitution or cyclopentene condensation. Strict control is vital for drug safety in autoimmune disease treatment.
Detection: UPLC-MS/MS with C18 column (1.8μm) and 0.1% formic acid-acetonitrile gradient; LOD: 0.002 ng/mL.
Formation: Arises from excess morpholine in cyclization steps; using molar-exact reagents reduces content by 65%.
Toxicity: In vitro studies show minimal impact on receptor binding; ongoing animal studies assess systemic toxicity.
NOTE！
We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!
WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com
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